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There was an increasing desire for the recognition of structural variations in aortopathy. Copy quantity variants identified in thoracic aortic aneurysms and dissections, bicuspid aortic valve associated aortopathy, Williams-Beuren problem and Turner problem tend to be discussed at length. Most recently, initial inversion disrupting FBN1 has been reported as an underlying cause for Marfan problem. In the past 15 years,
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