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Also, in the trial for the analysis process, all information will likely to be assessed anonymously. Exactly what impacts the efficacy of alendronate for prevention of glucocorticoid-induced (GI) fractures remains unclear. We aimed to explore the facets affecting alendronate's effectiveness, and further identify subgroup effects of alendronate in preventing GI fractures. We searched 3 databases. Random-effects meta-analysis had been carried out to synthesize risk ratio (RR) and 95% confidence inte