https://www.selleckchem.com/pe....ptide/dulaglutide.ht
The two major brain nicotinic acetylcholine receptors (nAChRs) involved in cognitive function are the α4β2 and α7 nAChRs. A "methyl scan" of the pyrrolidinyl ring was used to detect differences in the interactions of nicotine with these two receptors. Each methylnicotine was investigated using voltage-clamp and radioligand binding techniques. Methylation at each ring carbon elicited unique changes in nicotine's receptor interactions. Replacing the 1'-N methyl with an ethyl group or adding a second 1'-N methyl group significantly redu
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