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57%, p  less then  0.001) and RV EF (42 vs. 48%, p  less then  0.001) in the GA group compared to the non-GA group. There was no significant difference in HR or CI. After matching and PSM adjustment, the GA group had a significant decrease in LV EF (49 vs. 56%, p  less then  0.001), RV EF (41 vs. 48%, p  less then  0.001), CI (2728 vs. 3701 ml/min/m2, p  less then  0.001), and HR (72 vs. 79 bpm, p = 0.04). General anesthesia with sevoflurane results in depressed CMR-derived EF.Although the Fontan operation can improve outcomes, surviving patients st