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RESULTS Thirteen trials (n = 90 had been included in this analysis. When compared to placebo, fibrinogen concentrate significantly reduced the first 12-hour postoperative loss of blood, with a mean distinction of -134.6 ml (95% CI -181.9 to -87.4). Additionally somewhat increased clot firmness in thromboelastometry (FIBTEM) with a mean difference of 2.5 mm (95%CI 1.1 to 3.8). No significant differences had been shown within the unpleasant events connected with fibrinogen focus use, specifically occurren
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