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is registered with PROSPERO (registration number CRD42018105024) (registered on 29 August 2018). 1 year) of bisphosphonates was more significant in lowering breast cancer risk. Further randomized controlled trials are needed to verify this association. This trial is registered with PROSPERO (registration number CRD42018105024) (registered on 29 August 2018).Abnormally expressed long noncoding RNAs (lncRNAs) have been reported to affect the occurrence and progression of hepatocellular carcinoma (HCC) by modulating the autophagy axis. Ho