https://www.selleckchem.com/pr....oducts/n6-methyladen
An E logistic model for G4 neutropenia and a linear logistic model for G ≥ 3 thrombocytopenia, which retained platelets and albumin at baseline and body surface area, best fitted to AUC and AUC . AUC between approximately 1000 and 1700ng·h/L provided the best benefit/risk ratio, and the dose of 3.2mg/m provided median AUC of 1400ng·h/L, thus maximizing the proportion of patients within that lurbinectedin target exposure range. The relationships evidenced in this integrated E-R analysis support a favorable benefit-risk profile