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Multidrug resistance (MDR) is the significant buffer towards the successful treatment of chemotherapy. Substances from nature products working as MDR sensitizers offered new therapy strategies for chemo-resistant cancers customers. We investigated the reversal effects of nuciferine (NF), an alkaloid from Nelumbo nucifera and Nymphaea caerulea, from the paclitaxel (PTX) opposition ABCB1-overexpressing cancer tumors in vitro plus in vivo, and explored the root system