https://www.selleckchem.com/pr....oducts/lenalidomide-
Finally, endothelial cell proliferation, cell cycle, and apoptosis were measured. CHD mice presented with an elevated positive rate of RALB, endothelial cell apoptosis and levels of TNF-α, IL-6, IL-1β, yet a reduced IL-10 level. RALB was identified as a target of miR-495 and was downregulated by miR-495, which led to reduced expression of RALB, ICAM-1, VCAM-1, NF-κB p65, and phosphorylated NF-κB p65. miR-495 overexpression or RALB silencing decreased the levels of TNF-α, IL-6, and IL-1β, suppressed endothelial cell apoptosis
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