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First, is the biochemical data showing a role of ABCA7 in amyloid pathology. Second, genetic data identifying ABCA7 gene variants as loci responsible for the late-onset AD. These results point to the ABCA7 as a significant new contributor to the pathogenesis of AD.Poor air quality usually leads to PM2.5 warnings and affects human health. The impact of frequency and duration of extreme air quality has received considerable attention. The extreme concentration of air pollution is related to its duration and annual frequency of occurrence