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27), anxiety (P = .050; effect size, 0.29), and total sleep time (P = .068; effect size, 0.39). The rehabilitation program may improve health-related quality of life and sleep and alleviate anxiety in patients with esophageal cancer. A rehabilitation program comprising exercise and diet education is a feasible and low-cost intervention for improving quality of life of patients with esophageal cancer. Healthcare team members may consider it as a nonpharmacological treatment option for patients. A rehabilitation program comprising exercise