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despite this, the severe impact of disease on patient and family QoL outcomes can be as apparent in naïve patients as in systemically-treated patients at baseline. This article is protected by copyright. All rights reserved.The Rh(III)-catalyzed, consecutive double C-H oxidative coupling of free 1-naphthylamine and α,β-unsaturated esters through C-H/C-H and C-H/N-H bonds is reported. The one step reaction leads to the formation of biologically important alkylidene-1,2-dihydrobenzo[ cd ]indoles scaffolds. This efficient process is much mo