https://www.selleckchem.com/pr....oducts/deruxtecan.ht
The DNA damage response (DDR) is orchestrated by three apical signalling kinases ATM, ATR and DNA-PKcs. Despite their central roles, structural and biochemical understanding has remained limited, mainly due to their large size. Recent advances in cryo-electron microscopy allowed for the structural analysis of these kinases, revealing their overall architecture and providing high resolution structures of their active sites. Combined with novel biochemical insights it is now possible to dissect the elements that are important for activ