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We present extensive experiments on the three different applications using four biomedical imaging datasets. Experimental results show that our method exhibits remarkable performance and outperforms the compared methods.Androgen receptor (AR) is abundantly expressed in the preoptico-hypothalamic area, bed nucleus of stria terminalis, and medial amygdala of the brain where androgen plays an important role in regulating male sociosexual, emotional and aggressive behaviors. In addition to these brain regions, AR is also highly expressed in