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Purpose Generalizability is an important problem in deep neural networks, especially with variability of data acquisition in clinical magnetic resonance imaging (MRI). Recently, the spatially localized atlas network tiles (SLANT) can effectively segment whole brain, non-contrast T1w MRI with 132 volumetric labels. Transfer learning (TL) is a commonly used domain adaptation tool to update the neural network weights for local factors, yet risks degradation of performance on the original validation/test cohorts. Approach We explore TL usi