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Consistent with poor oocyte quality, the majority of Chtf18-/- oocytes fail to progress to metaphase II following meiotic resumption and a significant percentage of those that do progress are aneuploid. Collectively, our findings indicate critical functions for CHTF18 in ensuring both the quantity and quality of the mammalian oocyte pool. © The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction.BACKGROUND Sequence-binning techniques enable the recovery of an increasing number of genom
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