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The need for restrictive use of antibiotics has become a contemporary issue, hence the drive for reduction in the duration of perioperative antibiotic use without compromising care. The aim of this study was to compare the efficacy of short course versus long course antibiotic prophylaxis for caesarean section. This was a randomised controlled study in which I66 patients admitted for elective or emergency caesarean section at National Hospital Abuja were randomly allocated into two parallel treatment groups in 11 allocation ratio. The study group re