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Extended spectrum Beta-lactamases (ESBLs) and AmpC beta-lactamases (AmpC) are the common enzymes produced by gram negative bacilli, which are their main mechanisms of resistance to all generations of cephalosporins. Hence, this study aimed to determine the magnitude of ESBLs and AmpC producing gram negative bacilli (GN isolated from clinical specimens at International clinical Laboratories in Addis Ababa, Ethiopia. A cross sectional study was conducted from January to May 2018. From different clinical specimens, 338 GNB were isolated and
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