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We present an individual with intense exacerbation of chronic pain from breast ulcerations due to congenital lipomatous overgrowth, vascular malformations, epidermal nevis, spinal/skeletal anomalies/scoliosis (CLOVES) problem which was successfully addressed as an inpatient with a portable cryoneurolysis device. This is basically the very first reported use of cryoneurolysis in an inpatient setting to take care of acute-on-chronic discomfort in a nonsurgical client. The writers recommend regional anesthesiol
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