https://mirna2.com/index.php/i....ntrusive-cancer-mali
In this research, practices were developed to split up and identify the impurities in three representative 16-membered macrolides (josamycin, midecamycin and meleumycin) using a high-performance fluid chromatography coupled to high-resolution ion trap/time-of-flight mass spectrometry (IT-TOF MS). As a whole, 53 impurities were characterized within the positive mode of electrospray ionization, among which 28 novel impurities were found. The suggested frameworks of impurities were deduced predica