https://www.selleckchem.com/pr....oducts/usp22i-s02.ht
001). SBD was associated with significantly increased NLS (HR0.50; 95%CI 0.27-0.94, P=.03) in BSEP1 and BSEP2. A serum bile acid (sBA) concentration below 102 μmol/L and a decrease in sBA by at least 75%, each shortly after SBD, reliably predicted NLS of at least 15 years after SBD (each P less then .001). CONCLUSIONS The genotype of severe BSEP deficiency strongly predicts the long-term native liver survival, the risk to develop hepatocellular carcinoma, and the chance that surgical biliary diversion increases native liver survival.
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