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This in silico research aims to identify the best possible dosimetric trade-off for prescribing SFRT with volumetric modulated arc (VMAT) based stereotactic radiotherapy (SRT). Information and methods Eight spherical volumes defined "Gross Tumor Volumes" (GTVs) had been generated with diameters of 3-10 cm (with progressive tips of just one cm), simulating tumefaction lesions. The internal third section of each GTV (GTVcentral) ended up being selected to simulate the central hypoxic area a