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PURPOSE There is an increase interest on the potential chemoprotective effect of selective phosphodiesterase 5 (PDE5) inhibitors. Several authors have shown in vivo the immune-mediated anti-tumor effect of these inhibitors on tumors arising from the digestive tract. OBJECTIVES To test the potential effect of selective PDE5 inhibitors against colorectal cancer (CRC) onset previously observed. METHODS We used data from The Health Improvement Network database and identified an established cohort of 200 000 new users of low-dose aspirin and