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Stimulants Are the Most Effective ADHD Medication For Adults The most commonly prescribed medication used by health professionals to treat ADHD in adults is stimulants. They help by increasing the levels of neurotransmitters (chemicals) in your brain. This improves attention and reduces the risk of impulsivity. Antidepressants like Strattera (atomoxetine) and Wellbutrin/Zyban (bupropion) can also help manage ADHD. They increase the amount of norepinephrine within your brain. Stimulants Stimulants, also ref