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22%, and 97.90%, respectively. The results indicated that a small amount of ionic liquids as modifier of the two-phase solvent system could shorten the separation time and improve the separation efficiency of the alkaloids from the fruits. The ionic-liquid-modified high speed counter-current chromatography would provide a feasible way for highly effective separation of alkaloids from natural products. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Data quality