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In addition, the blood concentration of LA was detected over 21days or more after administration of M , and the absolute bioavailability was calculated to be about 100%. A depot formulation using C17MGE was useful to achieve sustained release of LA. A depot formulation using C17MGE was useful to achieve sustained release of LA. Topical therapy of local disease (e.g. skin) is advantageous over oral therapy since there is less systemic drug distribution (so fewer side-effects), no first-pass effect, etc. However, patient compliance with to
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