https://ro5126766inhibitor.com..../k3326x-and-other-c-
Intriguingly, OPC-specific IFN-γ signaling contributed to failed oligodendrocyte differentiation, that has been related to hyperactive Wnt/Bmp target gene phrase in OPCs. We found that PI-88, a heparan sulfate mimetic, directly antagonized IFN-γ to rescue human OPC expansion and differentiation in vitro and blocked the IFN-γ-media step up the recruitment period of remyelination. Right here, we show that the proinflammatory cytokine interferon-γ directly acts on OPCs to indu
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