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These models confirmed the popular deregulation of nitric oxide synthesis in the HbSS genotype, concerning arginine deficiency and increased levels of dimethylarginines, ornithine, and polyamines. Other discriminant metabolites were newly evidenced, such hexoses, alpha-aminoadipate, serotonin, kynurenine, and proteins, pointing to a glycolytic move and to the alteration of metabolites considered associated with nociceptive paths. Sharp remodeling of lysophosphatidylcholines, phosphatidylcholines, and sphingomyelins en
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