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GnRH/LH pulse amplitude and regularity drive oestradiol production, culminating in oestrus behaviour and a precisely-timed GnRH/LH rise, all of these tend to be interrupted by bad surroundings. Reactions to peripheral neuronal representatives give clues about systems, but do these medicines alter perception of stimuli, or suppress consequent reactions? In vitro scientific studies confirm some neuronal interactions between your HPA and HPO; and immuno-histochemistry clarifies