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of hosts are rather poorly characterized. Here, we present the transcriptional organization of the stability module and show that gene transcript dosage effect is an important determinant of the RA3 stable maintenance in different hosts.Streptomyces is well-known for biosynthesis of secondary metabolites with diverse bioactivities. Although oils have been employed as carbon sources to produce polyketide antibiotics for several industrial Streptomyces strains, the intrinsic correlation between oil utilization and high production of antibiot
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