https://www.selleckchem.com/pr....oducts/Elesclomol.ht
llular Aβo propagate excitatory synaptic alterations by promoting amyloid precursor protein (APP) processing. Our results also suggest that subsequently to APP cleavage two pools of Aβo are produced. One pool accumulates inside the cytosol inducing the loss of synaptic plasticity potential. The other pool is released into the extracellular space and contributes to the propagation of the pathology from diseased to healthy neurons. Pharmacological strategies targeting the proteolytic cleavage of APP disrupt the relationship between ext
Like
Comment
Share
