https://www.selleckchem.com/products/gs-9973.html
Two patients with germline BRCA1 deficiency acquired genomic alterations anticipated to restore HR through increased DNA end resection loss of TP53BP1 in one patient and amplification of MRE11A in another. RAD51 foci were acquired post-resistance in all patients with genomic reversion, consistent with reconstitution of HR. All patients whose tumors demonstrated RAD51 foci post-resistance were intrinsically resistant to subsequent lines of DNA-damaging therapy. CONCLUSIONS Genomic reversion in BRCA1/2 was the most commonly observed mecha
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