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ADHD Treatment For Adults The stimulants methylphenidate and amphetamine can boost the levels of certain brain chemicals. Nonstimulants like atomoxetine or antidepressants are slower than stimulants, however, they can be just as beneficial. The comorbidity of conditions can influence the response to ADHD medications. Physicians should treat the most severe symptom of any co-occurring disorder first, and then monitor whether the ADHD symptoms improve. Medication