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Bone marrow-derived mesenchymal stem cells (BMSCs) in postmenopausal osteoporosis designs exhibit loss of viability and multipotency. Identification regarding the differentially expressed RNAs in osteoporotic BMSCs could unveil the mechanisms underlying BMSC dysfunction under physiological conditions, which can enhance stem cell treatment and structure regeneration. In this study, we performed high-throughput RNA sequencing and revealed that the book very long non-coding RNA (l