https://acat-signal.com/index.....php/environmentally-
One method of resistance observed in around 10-20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate disease (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Utilizing huge client datasets, patient-derived organoids and cancer tumors cell outlines, we identify mSWI/SNF subunits being deregulated in NEPC and demonstrate that SMAR
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