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Further understanding and revealing the impacts of the PC on the biological behavior of GNPs can be a promising and important strategy to regulate and improve the performance of GNP-based biosystems in the future. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.Patients with severe hyponatremia and renal failure who require continuous renal replacement therapy (CRRT) are at risk for overcorrection of their sodium level due to preformulated isotonic replacement or dialysate fluids. Rapid correction of hyponatremia can lead to ser