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Advancement and also consent of the Sorting non-trauMatIc adoLescent joint ache (Laugh) device * an improvement and first affirmation examine. Frequent mutations included MED12, TP53, RARA and PIK3CA. Histological observations of increased cellular density and pleomorphism correlated with mutational burden. Phylogenetic analyses revealed disparate pathways of possible tumour progression. In summary, histological heterogeneity correlated with genetic changes in breast FELs.Obesity