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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can cause chronic underachievement and depression. This is particularly the case when they don't achieve their goals in terms of personal and professional. It can be difficult to make when there are symptoms that overlap between ADHD and depression. But identifying the symptoms is the first step toward finding treatment. 1. Feelings of Unworthiness Untreated ADHD and co-occurring disorders