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g., cardiorespiratory fitness) and the HRV derived parameters. Electrocardiogram (ECG) abnormalities increase the likelihood of heart failure (HF) but have low specificity and their occurrence is multifactorial. This study aimed to investigate the prevalence and association of major ECG abnormalities with clinical characteristics and outcomes in a large cohort of real-life HF patients enrolled to HF Registries (Pilot and Long-Term) of the European Society of Cardiology. Standard 12-lead ECG containing at least one of the following simpl