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When clinically validated, GANs have the potential to improve musculoskeletal imaging. Keywords Adults and Pediatrics, Computer Aided Diagnosis (CAD), Computer Applications-General (Informatics), Informatics, Skeletal-Appendicular, Skeletal-Axial, Soft Tissues/Skin © RSNA, 2021. To develop an unsupervised deep learning model on MR images of normal brain anatomy to automatically detect deviations indicative of pathologic states on abnormal MR images. In this retrospective study, spatial autoencoders with skip-connections (whi