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CONCLUSION Alcohol and tobacco dependents showed gingival inflammation, and less than half of them showed oral mucosa changes. Twenty-one protein candidates for biomarkers of oral disorders were identified in saliva. The two major oral disorders in number of candidates for biomarkers were head and neck cancer and periodontal disease. © 2020 John Wiley Sons A/S. Published by John Wiley Sons Ltd. All rights reserved.Bacopa monnieri (L.) is widely used in Ayurvedic medicine as a neural tonic for improving intelligence and memo