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The Most Effective ADHD Medication For Adults Stimulants are the first-choice treatment for adults suffering from ADHD. They regulate the levels of two chemical signals in the brain which control the attention. The most effective treatment for adhd for adults is Strattera (atomoxetine). It is an oral capsule that can be taken either with or without food. It works well for most people. It also lasts longer than the more sedatives, like methylphenidate or amphetamine. 1. Strattera Strattera (atomoxetine), a nonstimulant ADHD drug, functions differently than stimula