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Knockdown of , abrogated polarisation of epithelial cells in normal cells. Finally, expression was substantially reduced in the bronchial epithelium of COPD patients. Defect in gene signatures involved in tissue development and epithelial differentiation were implicated in COPD basal cells. One of the tissue developmental genes, HOXB2, is substantially reduced in bronchial epithelium of COPD patients. Since HOXB2 contributes to airway epithelial cell polarisation, we speculate that reduced expression of HOXB2 in COPD may contribute to a
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