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Most Effective ADHD Medication For Adults Most adults have found that medication helps to reduce their ADHD symptoms so they can focus, feel calm and have better relationships. Medicines can also help with other treatment options like psychotherapy. Adults with ADHD are most likely to benefit from stimulants. These include methylphenidate compounds and amphetamines. Adults may take long-acting medicines that are slow-acting but last 3 to 6 hours or short-acting medication several times per day. Stimulants The most effective ADHD treat