https://www.selleckchem.com/pr....oducts/favipiravir-t
The discrepancy in the sustained efficacy and resistance emergence between in vivo and in vitro models appears to be due to the resistance acquisition mechanism caused by mutation in the tonB-exbB-exbD region developing in the enriched media utilized in vitro. These studies reveal the in vivo bactericidal activity and the low potential for development of resistance among Stenotrophomonas evaluated under human-simulated exposures. The discrepancy in the sustained efficacy and resistance emergence between in vivo and in vitro mo
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