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Taken together, our results suggest that Nup153 has separable roles in NE and NPC formation in post-mitotic NE re-formation in concert with Mad1 and in interphase NPC assembly, independent of Mad1. Loss of positivity of antiphospholipid antibodies has been observed in clinical practice post-thrombosis in patients with SLE with secondary antiphospholipid syndrome (APS). Our study defined the frequency of this loss and the duration before positivity recurred. In this prospective study, patients with SLE having at least two positive antiph