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Copyright© Bentham Science Publishers; For any questions, please e-mail at [email protected] intent for this research was to develop pemetrexed diacid (PTX)-loaded gelatine-cloisite 30B (MMT) nanocomposite when it comes to prospective dental delivery of PTX and the in vitro, and ex vivo assessment. Gelatin/Cloisite 30 B (MMT) nanocomposites were prepared by blending gelatin with MMT in aqueous solution. PTX had been integrated when