https://www.selleckchem.com/pr....oducts/z-yvad-fmk.ht
Free energy and kinetics calculations of sodium permeation through the native and mutated VSD indicate as more favorable the formation of a cationic current in the latter. Overall, our simulations establish a mechanistic linkage between genetic variations and their physiological outcome, by providing a computational description that includes both thermodynamic and kinetic features of ion permeation associated with ω-currents.Kink formation is essential in highly bent DNA complexed with gene regulatory proteins such as histones to rel
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