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64 [95% confidence interval, 1.15-2.32]; p linear trend less then 0.001). This association was more apparent for ischemic (1.65 [1.12-2.45]; p linear trend less then 0.01) than for hemorrhagic stroke (1.29 [0.60-2.78]; p linear trend = 0.3). We further observed a borderline significant trend for a positive association between sTM and overall stroke risk (1.47 [0.99-2.19]; p linear trend = 0.05). CONCLUSIONS In this population-based study, circulating levels of ICAM3, an adhesion molecule shed by leukocytes, were associate