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This work may have immediate clinical implications, introducing a platform for predictive prodrug design and potentially overcoming hurdles in drug development.The ternary van der Waals material Nb2Six-1Te4 demonstrates many interesting properties as the content of Si is changed, ranging from metallic Nb3SiTe6 (x = 5/3) to narrow-gap semiconductor Nb2SiTe4 (x = 2) and with the emergence of one-dimensional Dirac fermion excitations in between. An in-depth understanding of their properties with different stoichiometry is important. Here we